Just clarifying that two days means one overnight.
The Central Valley path down I-5 is fast but boring but can be accomplished with no overnight.
Either way, you will encounter the monster known as Los Angeles area traffic.
This is the Yosemite forum so all topics are Yosemite. Just stay in Yosemite. :)
But seriously, if you want feedback for a general itinerary in California, use the state forum. There are some helpful tips in the Top Questions on the right side of the CA page. The Top Questions here are about Yosemite. These valuable topics are only visible on the full TripAdvisor website, not the app.
Where are you staying? When are you visiting? Are you staying long enough to enjoy various areas of the National Park?
And if you don’t have Yosemite reservations.....abandon Yosemite.
Instead on the 14th drive to and overnight in Monterey/Carmel. On the 15th, drive through Big Sur, and overnight in Cambria/Morro Bay/Pismo Beach or similar place in San Luis Obispo County. Depart early on the 16th on 101 through Santa Barbara for Los Angeles.
This is the Yosemite forum, so I'll assume you want to visit Yosemite. :)
Saturday, 14 March
Leave SF. Drive directly to Yosemite via Hwy 140 / Arch Rock Entrance along the Merced River. Park in the Valley Visitor Parking lot. Use the free shuttle to get around.
Drive to your lodging, unless you were incredibly lucky and found lodging in Yosemite Valley. That's the first topic in the Top Questions.
Sun, 15 Mar
All day tourism in Yosemite Valley. Enjoy! See those Top Questions.
Mon, 16 Mar
Drive to Mariposa Grove of Giant Sequoias, assuming that you are okay with a longer hike or walk. The shuttle won't be running. Walk 2 miles up the road, seeing some Big Trees along the way. Then walk 0.8 mile to the Grizzly Giant. Walk back.
Exit via the South Entrance and drive down Hwy 41 to Hwy 99 to Interstate 5.
Alternate plan.... visit Tuolumne Grove of Giant Sequoias during your time in Yosemite. It's higher elevation so will be cooler. There may be snow on the ground. But it's "only" 2.5 miles round trip for the walk down into the grove and back up.
Top Questions on the right (full TA website not the app) and the NPS website will be good resources for you.
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