Absolutely fine to take your children out to Pub Street. As the evening wears on it will get busier and the music coming from some of the bars will get louder. It gets particularly busy at each end of the street as there will be dozens of tuk tuk drivers touting for business (vehicles are not allowed to go into Pub Street in the evenings).
As long as you keep an eye on your children you will be fine.
I think your biggest worry would be the kids tripping over something, running into somebody, etc. It was busy but always seemed safe. As others said, a few of the roads are shut off to traffic, which is nice. Just be careful when you leave the streets that are shut off to traffic. It can be hard to navigate as an adult, and it's harder at night.
There will be tuk tuks at every road barrier. If you're going more than a couple blocks off of the main stretch, you can get one for pretty cheap to safely whisk you to your next destination.
Thanks everyone for your replies
I would avoid pub street like the plague, especially with children! There are so many nice restaurants in Siem Reap away from there. It’s like playa de las americas in Tenerife with tacky neon signs, drunk people & beggars everywhere! I was quite disturbed by the amputee beggars & I’m an adult.
Visit Pub St during the day - not crowded Visit after dark and it can be awful. Plenty of options for eating outside Pub St that will actually be a whole lot more authentic.
I agree that it would be better to go to Pub Street with your children during the daytime, perhaps for lunch. You haven’t mentioned their ages but if they are very young and are used to a quieter environment , it could be quite overwhelming for them. I’m used to travel and eating in various places but find that Pub Street at night is not an ideal place for dinner as you can’t hear yourself think and it’s like being in the middle of a crazy circus or something.
Just a short walk away outside the Pub Street area you’ll find many street side restaurants where the food is better, a good deal cheaper, it’s quieter and a good deal more pleasant for a family meal.
You may find your kids have other ideas! My daughter spotted a BBQ restaurant with a playroom from the tuktuk and pointed it out every time we went to and from the temples. Eventually we gave in and went there the last night.
What was it called, my 2 are 6 and 10. I remember when I was in Chaeweng Koh Samui many years ago and it was quite sleazy with lots of bar girls, im hoping Pub street isn't like that. I'll also take the advice of trying restaurants off the main strip/road
I would have an early meal and leave by 7 pm when so many drunks are around