Independent Black Forest locales dating back to medieval times, in 1971, Titisee and Neustadt (along with Rudenberg) banded together to form Titisee-Neustadt. (A few years later, nearby towns Langenordnach, Schwärzenbach and Waldau also joined the union.) Long known as a spa town, Titisee sits on the banks of the lake of the same name. Legend says the name came from Roman Emperor Titus, who was so taken by its beauty that he named it after himself. The area is great for hiking and winter sports.

If you’re after a winter sports holiday, you can’t find a more gorgeous place to do it than Interlaken, the popular Swiss resort town. There’s superlative skiing, toboggan rides, miles of sledding tracks (which, like the ski slopes, vary in difficulty), snowboarding… all with amazing views of the mountains. In summer, hike among the ibex at nearby Neiderhorn, or shop for watches in the town’s boutiques.

Once one of ancient Greece’s most important cities, today Syracuse (Siracusa in Italian) is a lively town of about 125,000 on Sicily’s southeast coast. The city overflows with amazing remnants from its long history. Romans, Vandals and Normans are but a few of those who ruled here after the Greeks. In Syracuse’s harbor, Ortygia Island (also called Città Vecchia or Old City) is the site of many of the main attractions, including the seventh-century cathedral and the Fountain of Arethusa.

Known for its markets and its striking 19th-century limestone architecture, Kingston is a great base for exploring the Thousand Islands and the St. Lawrence River and its national park. Visit Wolfe Island on the free ferry, or hunt for antiques in nearby villages.

Allentown, is the largest of the three Pennsylvania cities that make up the Lehigh Valley. Formerly an industrial hub, Allentown is probably most well known as the subject of the eponymous Billy Joel song. The long history of Allentown has left it with an impressive architectural heritage that includes buildings such as the neo-Roman Art Museum, which contains a reconstructed room designed by Frank Lloyd Wright. The city is also home to the Dorney Park and Wildwater Kingdom amusement park.

Located on the shores of Lake Michigan, Milwaukee is perhaps best known for its famous breweries and the Major League Brewers, but there's more to the city than beer and baseball. Milwaukee is rich in historical and cultural attractions, making it the perfect place for a weekend of exploring. Check out the newly expanded Milwaukee Art Museum or the Mitchell Park Horticultural Society, which hosts an annual show of the same flora and fauna seen in Georgia O'Keefe's paintings. Those interested in the city's history can visit the grand Pabst Mansion, former home of one of the city's famous beer barons, or the Milwaukee Public Museum, to see what life was like in Old Milwaukee. If the kids are along, don't miss the Milwaukee County Zoo or the Betty Brinn Children's Museum. Of course a trip to the "Genuine American City" would not be complete without a tour of the Miller Brewing Company and a Brewers game at Miller Park.

Lafayette is part college town, part natural landscape and part lively urban center. Across the Wabash River in West Lafayette, Purdue University draws a diverse young student population to the city. A walking tour of downtown Lafayette reveals a historic core of Victorian architecture, unique shops and public art. Nature abounds in the city and area parks, including Columbian Park, the Celery Bog wetlands, the Jerry E. Clegg Botanical Garden along Wildcat Creek and Wolf Park in Battle Ground.

If you’re into eating locally and supporting sustainable agriculture, go to Asheville—and eat, eat, eat. This town of less than 100,000 people has 17 farmers’ markets, and the local restaurant scene is all about taking advantage of the seasonal produce sold there. And don’t miss the area’s microbreweries.

Charming Savannah is the picture of antebellum hospitality, thanks to period architecture and oak-lined streets. It’s tempting to spend your trip just relaxing on vast verandas and sipping mint juleps, but there are plenty of historical sites and museums to explore. Haunting (and possibly haunted) Bonaventure Cemetery is one of the hallmarks of the city, featuring beautiful obelisks, masses of flowers, and ivy-covered crypts. Dine on fresh seafood and creamy grits for a taste of Savannah home cooking.