Lucerne is an ancient town with strikingly modern sensibilities. One of Europe’s oldest covered bridges serves as its centerpiece, and fresco-adorned historic houses line the streets, but it’s also home to the cutting-edge KKL, a concert hall and art gallery. Take the cableways up the Pilatus, Stanserhorn or Rigi mountains for breathtaking views, or see Lake Lucerne on a steamship cruise.

Lying on picturesque Lake Constance (or Bodensee in German), Konstanz has been a city since the first century AD, later gaining prominence as a religious center and then as the site of the only bridge crossing the Rhine River. The Old Town is one of Konstanz’s main attractions and is home to the city’s famed cathedral, originally dating from the 7th century. Due to a border anomaly, Konstanz lies on Switzerland’s land mass, and the Swiss town of Kreuzlingen is just a short walk away.

The city of Freiburg im Breisgau sits austerely on the edge of the Black Forest. Home to one of Germany’s oldest universities and a Gothic sandstone cathedral, it’s a hub for academics and medieval history buffs. Chug German suds at a local brewery, then hop a cable car up Schauinsland mountain, where astounding views and a solar observatory await.

If you’re after a winter sports holiday, you can’t find a more gorgeous place to do it than Interlaken, the popular Swiss resort town. There’s superlative skiing, toboggan rides, miles of sledding tracks (which, like the ski slopes, vary in difficulty), snowboarding… all with amazing views of the mountains. In summer, hike among the ibex at nearby Neiderhorn, or shop for watches in the town’s boutiques.

Bristling with beautiful lakes, splashing rivers, rugged peaks and looming castles, Vorarlberg is tucked between Switzerland and Germany. This spirited state is dotted with Bauhaus-inspired architecture, eco-friendly dwellings and tiny towns, bristling with spires. Capital Bregenz is the main draw in this alpine locale. Cobblestone streets and a lovely lakeside setting add to its charms. Renowned for its cheese and dairies, Vorarlberg is also a popular spot for skiing and other winter sports.

Fairytale villages, thermal baths, casinos and pine and birch-blanketed mountains beckon travelers to southwestern Germany's Black Forest. Scenic drives and train trips showcase the best of the area. Skiing, hiking, mountain climbing, boating and ice-skating are popular activities. Baden-Baden's Roman-Irish baths, 19th-century performance hall, casino and fresco-adorned Pump Room are much visited. Gothic masterpiece Freiburg Cathedral and its famous Boys' Choir also draw visitors.

A magnet for skiers and hikers, these dramatic peaks – including the iconic Matterhorn – range from 3,000 to 15,000 feet and spread across three-fifths of the country. Abundant glaciers, scenic valleys and gorgeous alpine lakes add to the region's visual appeal. The Glacier Express train travels the 7.5-hour route through the Swiss Alps from Zermatt to St. Moritz, passing through fairy-tale villages and over 291 bridges along the way.

This Italian-speaking region in Southern Switzerland is on the border with Italy. Bellinzona is the capital, and Lugano is the most important city in the canton, known for its beautiful waterfront, steep hillsides and gorgeous lake views. Castelgrande is a lovely medieval castle overlooking the city that has recently been restored. The Centovalli Railway is a scenic train that operates between Locarno, Switzerland and Domodossola, Italy, traveling through the breathtaking "Hundred Valleys." Lake Como is nearby, the home of People magazine’s “Sexiest Man Alive,” George Clooney.

Getting sick on vacation is a major drag, but if you have to be under the weather, Montpellier is an ideal place to do it. People have studied medicine here for centuries—the Moors established medical schools in the 9th century, and the Université Montpellier’s school of medicine was founded in 1220. Once the local docs give you a clean bill of health, explore the cathedral, mansions and opera house.

The largest and many say most beautiful island in the Bay of Naples, Ischia is renowned for its curative spas. Ferries and hydrofoils connect Naples to Ischia Porto, the main town. Nearby at Ischia Ponte (connected to the main island by a foot bridge) are the magnificent Castello Aragonese and Guevara Tower. Forio on the island’s west coast, Lacco Ameno in the northwest and Sant’Angelo in the south are the liveliest resort towns. Casamicciola Terme in the north is one of Europe’s oldest spas.

Catania has been a prize of many empires over the centuries, from Greeks to Romans to Arabs to Normans to Spaniards (to name a few). But its citizens have a more dangerous enemy right in their backyard—Mount Etna, Europe's largest and most active volcano, which destroyed the city with earthquakes and lava flows in 1693. Look closely at the baroque buildings dating from after the eruption—you'll notice a creative use of lava.

From ornate mansions to ocean views, this charming city - the largest in Maine - will enchant you. Saunter down the brick sidewalks and cobblestone streets of the revitalized Old Port District, where you can browse through bookstores, explore craft shops and eat to your heart's content. Visit the Portland Head Light, which dates back to 1791, and is the oldest lighthouse still in continuous use in the U.S. The great poet Henry Wadsworth Longfellow is the city's native son, and you can visit his childhood home, the Wadsworth-Longfellow House. With kids in hand, enjoy the highly interactive Children's Museum of Maine. And then go next door to the calmer Portland Museum of Art, a small, but eclectic museum with Impressionist works, Maine landscapes by Homer and Wyeth and other collections. Land or sea is an option here, so if you're tired of the street life, take one of the popular scenic cruises or whale watches, or hop on a ferry to the islands in Casco Bay. At the end of the day, and without kids in hand, unwind and rest your tired feet at one of the city's brewpubs.

Natural beauty abounds in the state of Uttaranchal's Lake District. Boaters flock to hill-ringed Naini Lake, which according to mythology is one of the emerald eyes of Shiva's wife. A hike or horseback ride to the top of Naina Peak (aka China Peak), the highest point, provides stunning views of the snow-capped Himalayas. To share a prime vantage point with family members of all ages, take the aerial lift up to Snow View; there's also a small marble temple at the top dedicated to Dev Mundi.

The former home of three of America's founding fathers, and the current home of the University of Virginia, the city of Charlottesville, Virginia is suffused with an appreciation of history and intellectual vigor. Take a tour of the university campus and walk through grassy malls and grand buildings designed by Thomas Jefferson, or peak into the dorm room once occupied by Edgar Allen Poe. The great homes of America's early presidents, Monroe, Jefferson and Madison, are also open to the public.

Like all of the U.S. Virgin Islands, St. Thomas has plenty of opportunities to lounge on the beach, splash in the sea, or amp it up with watersports. It also boasts a bountiful duty-free shopping scene – just be prepared to brave the cruise ship crowds. Charlotte Amalie swells with Danish colonial architecture and pirate legend. Shiver ye timbers at Blackbeard’s Castle, then work up an appetite by climbing the historic 99 Steps, constructed from the ballast bricks of 18th century Danish ships.

Among the best golf destinations in the world, Punta Cana is the very picture of leisure. Several of the courses have been designed by professional golfers, making for the perfect sort of kicked-back challenge that you want on a golfing vacation. The beaches here are simply perfect: calm, warm waters that gently lap at stretches of fine white sand. Thrill yourself with a zip-line adventure, clap along with traditional Dominican music at a cultural performance, or explore the magical lagoons of the Indigenous Eyes Ecological Park.