Lying on picturesque Lake Constance (or Bodensee in German), Konstanz has been a city since the first century AD, later gaining prominence as a religious center and then as the site of the only bridge crossing the Rhine River. The Old Town is one of Konstanz’s main attractions and is home to the city’s famed cathedral, originally dating from the 7th century. Due to a border anomaly, Konstanz lies on Switzerland’s land mass, and the Swiss town of Kreuzlingen is just a short walk away.

Located on the Rhine River near the borders of France and Germany, Basel contains the country's highest concentration of museums. The culture-centric city, site of the world's most influential art market each June, is also home to the lovely Munster Cathedral, made of red sandstone with a multi-colored tile roof. Green spaces abound, including the popular zoological gardens in the city center. Switzerland's largest site of Roman ruins, Augusta Raurica, are an easy day trip to the east.

The city of Freiburg im Breisgau sits austerely on the edge of the Black Forest. Home to one of Germany’s oldest universities and a Gothic sandstone cathedral, it’s a hub for academics and medieval history buffs. Chug German suds at a local brewery, then hop a cable car up Schauinsland mountain, where astounding views and a solar observatory await.

The only way to reach lovely Murren is by taking a series of trains and cable cars. Once you’re there, you’re walking or biking around this charming car-free village. But it’s well-worth the trek, especially if you’re a skier or snowboarder. There are 32 miles of trails plus lots of off-piste opportunities. The sledding is even better. Take a cable car to the summit of Schilthorn for epic alpine views.

Colmar is a photographer's dream, with its labyrinth of cobbled lanes, flower-lined canals, and timber-framed houses painted in a rainbow of pastel hues. It's the quintessential Alsatian town, brimming with traditional restaurants and surrounded by vineyards and medieval castles.

In progressive Berlin, the old buildings of Mitte gracefully coexist with the modern Reichstag. Don't miss top historic sights like the Berlin Wall, Checkpoint Charlie, the Brandenburg Gate and Potsdamer Platz. The city's great zoo makes for a fun break from touring the staider attractions.

Georgia’s capital, Tbilisi, is straight from the pages of a Gothic fairytale. A deep valley forms the backdrop to brightly colored turrets, cobblestoned streets, and a burgeoning art scene, while warm Georgian hospitality permeates the mix of contemporary and traditional restaurants serving up local favorites.

Hilly Cincinnati boasts a thriving arts scene, major league sports teams, a world-class zoo and aquarium and a revitalized riverfront with shopping, clubs and restaurants. Located on the Ohio River in southwestern Ohio, Cinci claims more than 4,000 restaurants, and more chili restaurants than any other city in the world. Adrenaline-junkies will want to visit the nearby Kentucky Speedway and Paramount's Kings Island, home of the tallest and fastest wooden roller coaster in the world.