Whether rocking out to music legends inside the Rock and Roll Hall of Fame or viewing Monets and Picassos at the Cleveland Museum of Art, Cleveland is a city that mixes equal parts grit and sophistication. Nosh award-winning food in historic buildings, tip back some craft beers amid a Lake Erie beach party or cheer on a championship team with a hardball of locally distilled spirits. All in Cleveland.

With an average of 320 days of Florida sunshine each year – and 27 miles of sugar-white sands bordering the clear, emerald green waters where the Gulf of Mexico and St. Andrew Bay converge – Panama City Beach is a favorite of travelers seeking an affordable beach vacation with year round offerings. The region also features exciting on- and off-shore attractions, including St. Andrews Park and Pier Park, that offer something special to adrenaline-seekers, eco-tourists, families and couples alike.

Houston hums with an energy and independent spirit all its own. A leading cultural and culinary destination in the South, the city is home to over 11,000 restaurants featuring cuisine from more than 70 countries. The thriving arts scene includes resident opera, ballet, symphony and theater companies. The Museum District houses 19 museums, all within walking distance. Be sure to visit Space Center Houston, where you can visit NASA’s Historic Mission Control at the Johnson Space Center.

Sunny Cancun has much more to offer than its party-town reputation might suggest. Plenty of gorgeous, drama-free family resorts cater to folks who want to experience the tropical Yucatan climate. There are significant Mayan ruins here, such as El Rey and the Yamil Lu’um, a crumbling tower of pale gray stone. Learn more about this ancient civilization at the Museo Maya de Cancun. For a literal taste of Mexico, take a tour of the Museo Sensorial del Tequila.

One of the top diving destinations in the world for its bright storybook coral reefs, the island of Cozumel is also home to a variety of natural beaches. Choose a beach with soft white sand for relaxing, or snorkel off a rockier vista. A destination for both adventure and romance, Cozumel has a year-round Caribbean climate, untrammeled jungle and abundant nightlife.

From Alberta’s southwestern border north into British Columbia, the Canadian Rockies are a network of provincial and national parks that collectively make up a UNESCO World Heritage Site. Banff and Jasper national parks are connected by the Icefields Parkway, one of the most scenic drives in the world. The towns of Canmore, Banff, Lake Louise and Jasper are hubs for adventures including hiking, horseback riding, rafting and wildlife viewing. Accommodation ranges from hotels to mountain lodges.

Greater Palm Springs is an oasis for art, culture, adventure and relaxation. Take in the views from the Palm Springs Aerial Tramway, the world’s largest rotating tram car, before exploring exhibits at the Palm Springs Art Museum and its Architecture & Design Center. Visit the Empire Polo Club, home of the Coachella Music & Arts Festival and Stagecoach Country Music Festival. Dozens of spas in Desert Hot Springs let you soak in the healing mineral waters that flow beneath the city.

You'll find rugged beauty and a slow pace in the Cinque Terre. Named for the five towns of Monterosso, Vernazza, Corniglia, Manarola and Riomaggiore, this portion of the Italian Riviera is a UNESCO World Heritage Site. Cars aren't allowed, so take local trains or ferries to go from town to town—or walk one of the spectacular trails that connect them.

So splendid was medieval Verona that its reputation alone inspired Shakespeare to set two plays here (Romeo and Juliet and The Two Gentlemen of Verona). Though its connection to the actual Capulets is tenuous at best, the so-called Juliet's House draws half a million tourists per year, many of them keen on reenacting the balcony scene. Don't miss the Roman amphitheater and the Palazzo Barberi.