One of southeastern Sicily’s UNESCO-listed baroque cities, Noto is famed for its opulent architecture and surfeit of beauty. Its 18th-century cathedral is a local highlight, as is Caffe Sicilia, which is rumored to make some of the best gelato in all of Italy.

Once known for smog, traffic and tacky architecture, Athens is a city reformed thanks to fortunes brought by the 2004 Summer Olympics. Spotless parks and streets, an ultra-modern subway, new freeways, an accessible airport and all signs in perfect English make the city easily negotiable. Meriting more than a stopover en route to the islands, sophisticated Athens sites include many pillars of Western history, from the Acropolis to the Temple of Olympian Zeus, as well as treasures in the National Archaeological Museum.

When most people think of Zermatt, they think of one thing: The Matterhorn. This ultimate Swiss icon looms over Zermatt, first drawing visitors here in the 1860s. The village of Zermatt itself is lovely and car-free, with old-fashioned brown chalets and winding alleys. (Don’t worry, you don’t have to walk everywhere—there are electric vehicles and horse-drawn cabs.) Skiing in the region often lasts through early summer, but when the weather’s warmer, it’s a great time to hike.

The largest city in Switzerland is a major contemporary art and shopping destination. Important artworks are displayed in the Kunsthaus and the Rietberg Museum, while those who consider shopping an art can hone their skills along Bahnhofstrasse and Niederdorf. Chagall's stained glass windows in the Fraumunster amaze and Zurich's 500 clubs and bars, including several in swimming pools, pulse with life 'til the early hours. This city on Lake Zurich has excellent public transit and a free bike rental system.

A peaceful town on the northern coast of Morocco, Asilah is a tranquil and beautiful destination on the Atlantic Coast. Offering a refuge from the nearby bustling cities of Tangier and Tetouan, Asilah features deserted, quiet beaches and a relaxing atmosphere. The town has Mediterranean-influenced buildings, including whitewashed houses with blue accents on walls and doors. The array of houses decorated with paintings highlights the island's reputation as an artists' hangout.

Los Cristianos was a humble fishing village before it became known as a convalescent resort for Swedes. Now it’s a playground for beachgoers from all over Europe, thanks to sunny weather and plentiful hotel options. At night, you’ll find a lively bar scene.

Now that casinos have spread in South Africa, Sun City is no longer the only gaming hotspot in the country, but it's still visually dramatic. Located two hours from Johannesburg, it's a sprawling complex of luxury hotels, restaurants and Vegas-style shows on the edge of Pilanesberg Game Reserve.