As Baja California Sur’s capital, La Paz is mostly used as a jumping-off point for Cabo San Lucas’ beach resorts. However, its old-world charm and pleasant waterfront promenade featuring international art and restaurants overlooking the grey whale–inhabited water are reasons worth sticking around.

“Life’s a Beach” all right on Pensacola Beach where building sandcastles, body surfing and beachcombing are popular pastimes. Away from the sands, there are several don’t miss sights for the entire family, including the National Aviation Museum, which features 150 vintage aircraft, flight simulators and an IMAX Theatre, Fort Pickens, an historic military fort built in 1829, and the Pensacola Lighthouse, the oldest lighthouse on the Gulf Coast and also the tallest, standing 151 feet tall on a 40 foot bluff. To immerse yourself in the history of Pensacola, stroll the historic village, a pedestrian-friendly area with furnished historic homes, unique museums and the Colonial Archeological Trail. For the white dimpled ball set, try teeing up at Lost Key Golf Club, a target golf set up designed by Arnold Palmer and Marcus Pointe Golf club, an Earl Stone design. Don’t forget, there’s also great deep-sea fishing and other water activities like sailing, kayaking, diving and snorkeling to be actively pursued on Pensacola Beach.

Saint Augustine is a luxurious, romantic vacation spot—you’ll find classic hotels and intimate restaurants. Those can be a dime a dozen, though. What sets Saint Augustine apart is its history—it’s the oldest European settlement in the U.S. And nowhere else in the world can you taste the waters of the Fountain of Youth Archeological Park (where Ponce de Leon may have landed). Who knows, if you vacation here, maybe you won’t need that Botox!

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

One of the top diving destinations in the world for its bright storybook coral reefs, the island of Cozumel is also home to a variety of natural beaches. Choose a beach with soft white sand for relaxing, or snorkel off a rockier vista. A destination for both adventure and romance, Cozumel has a year-round Caribbean climate, untrammeled jungle and abundant nightlife.

Stretching 126 miles south toward Cuba, the stunning Keys are a perfect escape. Highlights along the way include Key Largo, Islamorada, Marathon, Big Pine Key and the irrepressible Key West. Get up close with an amazing array of fish while snorkeling, diving or fishing in the warm turquoise waters. Creeks, coral and costumed spectacles are other lures along the way. Highway 1 is a spectacular ribbon tying together the islands and atolls of this paradise between the Gulf of Mexico and the Atlantic.

Tamarindo is a prime spot for surfing and sportfishing, diving and sunning. Nesting leatherback turtles do their thing along the beaches from October to May and, for some nesting of your own, gorgeous beach houses, B&Bs and luxury hotels line the sunny sands. Shopping and dining options are superb and plentiful, perfect for sampling the true flavors of Costa Rica.

A diverse multicultural city of almost 1.3 million, Panama City offers a lot more than an up-close view of the Canal. Shantytowns slink up alongside shiny high-rise condos. The Old City is an atmospheric labyrinth of churches, plazas and palaces. Fifteen miles from downtown Panama City, Soberania National Park is an excellent destination for hiking and birding. For a fascinating look at the canal, take a taxi or local bus to Miraflores Locks Visitor Center and look down on the traffic below.