Bristol is a quirky British city with beautiful hilly vistas and plenty of historic sights to explore. Anyone interested in ships will have a blast aboard Brunel’s SS Great Britain, the world’s first great oceanliner, and the Matthew, a replica of the ship upon which John Cabot sailed to America in the 15th century. The graceful Clifton Suspension Bridge is another must-see.

More than just a stage for the annual “Running of the Bulls” festival, Pamplona offers a rich taste of Spain’s northern Navarre region. Medieval walls surround a walkable old town, where Basque-style tapas bars rub shoulders with Gothic cathedrals and abundant green spaces.

A coastal town just 20 miles west of Lisbon, Cascais was once a small fishing village, but its idyllic scenery attracted the attention of artists, writers and expelled European nobility in the 20th century. Today, it still attracts high society, but all society comes in force to enjoy the gorgeous beaches and adventure options like sailing and surfing. The Conde de Castro Guimarães Museum, a former palace, is now open to the public and displays an impressive collection of art and artifacts.

Getting to hilltop Orvieto is half the fun, with the choice of ascending by escalator or funicular cable car. The strategically built old town is free from modern-day traffic, inviting visitors to enjoy a taste of medieval Umbria—and a glass of famous Orvieto Classico wine.

Rome wasn't built in a day--and you'll need much more than a day to take in this timeless city. The city is a real-life collage of piazzas, open-air markets, and astonishing historic sites. Toss a coin into the Trevi Fountain, contemplate the Colosseum and the Pantheon, and sample a perfect espresso or gelato before spending an afternoon shopping at the Campo de’Fiori or Via Veneto. Enjoy some of the most memorable meals of your life here, too, from fresh pasta to succulent fried artichokes or a tender oxtail stew.

Whether you’re a high roller or a low-key lounger, Las Vegas has something to suit your vacation taste. Sample fare from top chefs and cornucopian buffets, try your luck at one of the world’s premier casinos, or take in a spectacular show. Just wandering the Strip is enough to get your heart pumping. Once you’ve had enough of the razzle-dazzle, wave hello to the toothy sea life at the Mandalay Bay Shark Reef, hike Red Rock Canyon, or visit the Neon Museum, where old signs take on new life.

Here’s your day in Calistoga: Yoga. Massage. Spa lunch. Hike. Wine-tasting. Facial. Mud bath. Gourmet dinner (with more wine). Dip in a mineral pool. Does it get more relaxing than a spa town built around natural springs in the middle of wine country? We don't think so.