Surrounded by one of Germany's largest wine-growing regions, Stuttgart beckons cultural junkies with its acclaimed ballet, opera and philharmonic, while auto fans get revved up over the Mercedes Benz Museum. There's more green space than urban sprawl in the festival-friendly city, home to Europe's largest zoo and botanic garden combo, the Wilhelma. The WŸrttembergisches Landesmuseum, in one of the city's oldest structures, traces area history from the Stone Age. Buses or subway provide handy transport.

The largest city in Switzerland is a major contemporary art and shopping destination. Important artworks are displayed in the Kunsthaus and the Rietberg Museum, while those who consider shopping an art can hone their skills along Bahnhofstrasse and Niederdorf. Chagall's stained glass windows in the Fraumunster amaze and Zurich's 500 clubs and bars, including several in swimming pools, pulse with life 'til the early hours. This city on Lake Zurich has excellent public transit and a free bike rental system.

Toronto's neighbor Mississauga has more than 480 parks and woodlands for you to explore. Stroll the Waterfront Trail, rent a boat at the marina or spend a day at the racetrack. It's also called Ontario's shopping capital, with everything from shopping centers and outlet malls to picturesque village-style shopping streets.

New Orleans is full of life—but with a laid-back energy that sets it apart from other cities. You’ll wanna soak it all in: impromptu jazz performances up and down Frenchmen Street, the ding of the St. Charles Streetcar, moss-draped trees in the famous Garden District…even its gothic, above-ground cemeteries. (The city’s said to be one of the most haunted in America.) For some, NOLA will always be all about Bourbon Street, but for travelers looking to take it slow, the city’s distinct blend of cultures—including Creole and Cajun—means there’s tons to see, explore, and yes, eat.

You're on island time the moment you set foot in Jamaica. Ocho Rios, a port of call for many cruise lines, also boasts some of the most luxe resorts and spas in the Caribbean. And once you've had your stresses melted away in the island sun, you can head out for a night of dancing and reggae music.