Ten million people call vibrant, passionate, sprawling Bogota home. The energy of this metropolitan heart of Colombia is in part fueled by its hundreds of eclectic and authentic dining hot spots, fantastic wines, and frequent foodie festivals. Ask the locals where they like to eat, then walk off your empanadas and aji with a stroll through the historic district of La Candelaria or during an indulgent shopping adventure on the North Side.

Boasting almost exclusively Mediterranean Revivalist buildings and urban planning following the City Beautiful movement, Coral Gables is an elegantly laid out, pedestrian-friendly city boasting tropical foliage, charming boutiques and architectural grandeur. Historic landmarks such as the Biltmore Hotel and Merrick House provide a document of the history of the City Beautiful, while the crystalline Venetian Pool provides relaxation in a setting of exquisite beauty.

Home to two of America's most prestigious universities, Cambridge exudes a certain intellectual quirkiness. A mix of historical haunts, student hang-outs, alternative art and culture venues, vintage clothing shops, bookstores and ethnic restaurants, the city is, well, really cool. Although it is located just across the Charles River from Boston, Cambridge has a distinct vibe that is noticeable immediately. Start at Harvard Square, a hub of activity and mishmash of trendy stores, outdoor cafes and colorful local characters. Pick up a walking tour map at the visitors information booth in the center of the Square. The route will take you past many important landmarks including the Mount Auburn Cemetery, Tory Row and the Longfellow National Historic Site. Harvard University offers student-led tours through the illustrious buildings and monuments of its sprawling campus. Art and architecture buffs should meander around the M.I.T campus, which includes outdoor sculptures by masters such as Picasso and 20th-century buildings designed by modern greats like Eero Saarinen and I. M. Pei. Along the way, browse through bookstores, stop to watch street performers and grab a coffee at an outdoor café to take in all this captivating city has to offer.

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theater, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

Get major-city sophistication in a location that is one of the world’s natural wonders. Obviously a hub for those seeking the Rocky Mountain ski slopes, Denver is also home to four major sports teams, major museums and a wide variety of neighborhoods that make the city a destination in its own right.

Hollywood beckons to tourists who long for a brush with Tinseltown glamor. Tour movie studios, slip your hands into the famous prints at the TCL Chinese Theatre, or indulge in a celeb sighting at one of LA’s white-hot nightspots. Spot your favorite star while shopping at The Grove, or forget all about the famous eye candy as you take in the iconic artwork at The Getty Center. For a different type of star-gazing, peek through the telescopes at the Griffith Observatory.

Looking out over the city of St. John's, you may be reminded of a mini San Francisco (minus the cable cars). St. John's provides the ideal balance between nature and nightlife, from the East Coast Trail and its stunning scenery to the colorful entertainment district along George Street. Although it's the largest city in Newfoundland, the vibe is still very small-town. You'll feel welcome in the City of Legends!

Although it's also the location of the Latin America's largest seaport, Santos isn't just a boring port town. The city of 420,000, just 75 kilometers from São Paulo, features a seven-kilometer stretch of beach divided into just as many social cliques as you'd find on Ipanema. A verdant promenade separates the beach from the seafront condos and hotels, along which families and friends walk, amble, bike, skate, rollerblade, throw frisbees, you name it. Less sandy points of interest include the Museu do Café Brasileiro (Brazilian Coffee Museum), the Aquário Municipal (City Aquarium), the Orquidário Municipal (City Orchid Garden) and the Neo-Gothic Santos Cathedral.

Welcome to bustling San Jose, where Silicon Valley meets Spanish history and modern edifices sit alongside meticulously restored 19th-century buildings. Such is the contrast of this city rich in tradition and, thanks to the tech industry, just plain rich. Five star-hotels and fine restaurants line the streets of the restored downtown area, and the cultural scene is thriving with museums, theater and art to rival any world-class hub. Don't miss the Tech Museum of Innovation, an exploration of Silicon Valley and its impact on the area. History buffs will relish the old mansions and can delve into the city's past at the History Museum of San Jose. Save time for a round of golf or the locals' other favorite pastime, sipping coffee and people-watching at a crowded cafe.