Sedona is a true oasis, a vacationer’s paradise in the middle of the Arizona desert. Here, you’ll find resorts and spas, canyons and red rock formations. Bell Rock and Oak Creek Canyon are great hiking spots, and the dramatic architecture of the Chapel of the Holy Cross is a religious experience itself. When the sun dips down below the horizon it introduces the best show in Sedona: the night sky.

Topnotch golf courses, art galleries and seals share the dramatic oceanside landscape of La Jolla, an affluent community 15 minutes from downtown San Diego. Swimmers, snorkelers and kayakers dip into La Jolla Cove, where the protected waters shield an abundance of bright orange Garibaldi fish and sea caves indent the cliffs. The Museum of Contemporary Art San Diego, the family-friendly Birch Aquarium and the acclaimed La Jolla Playhouse deliver breaks from the sun.

If you're looking for some great Florida beaches but aren't necessarily interested in a mega-resort or theme park atmosphere, Pensacola might just be the place for your perfect weekend. Home to Gulf Islands National Seashore, the city offers some of the best fishing and boating in the area. Inland, canoeing enthusiasts won't want to miss the beauty of the Blackwater River. Closer to town, the city has a proud military heritage, which can be seen at attractions like the National Museum of Naval Aviation and the Pensacola Naval Air Station.

Dubbed the Queen City, Charlotte reigns over a 300-square-mile (482-square-kilometer) hodgepodge of neighborhoods that spin out from the banks of the Catawba River. From brewery-heavy art districts to historical corridors dripping in charm, consider Charlotte a crowd pleaser.

Since the redevelopment of the Inner Harbor in the late 1970s, Baltimore has set the standard for urban renewal. While a good part of the city's action centers around the fun and festive Harbor area, where street entertainers, open-air concerts, fireworks and parades abound, the surrounding neighborhoods offer all sorts of interesting landmarks, unique shops and delicious restaurants. Wander around Fells Point, the oldest section of Baltimore, reminiscent of an old English village, complete with pubs and cobblestone streets. Take the kids to the aquarium and check out the imaginative creations at the American Visionary Art Museum. Or stop by the Babe Ruth Birthplace and Museum for an in-depth look at the Great Bambino's life. Baltimore is also renowned for its African-American heritage sites, plus festivals and cultural events that take place throughout the year. From historic places and harbor cruises to family friendly attractions and fabulous neighborhoods, Charm City is one of the top tourist destinations in the United States.

Forget fashionable footwear, only your most comfortable shoes will cut it in Killarney. It's a walking town, and every trail is a history lesson. Journey on foot through Ireland's first national park, 26,000 acres of woodlands, sandstone mountains and low-lying lakes. When your feet wear out, take in Killarney National Park via boat from Ross Castle. And because there are more hotel beds in Killarney than in any other Irish town or city (besides Dublin), you'll always have a place to rest your head (and feet).