From family-friendly activities to professional sports teams, museums and galleries, Rochester has something for everyone. Enjoy the scenic Erie Canal, Genesee River and Lake Ontario. Don't miss the Strong National Museum of Play (America's second-largest children's museum) or the International Museum of Photography. Be sure to sample one of Rochester's famous "white hots," Rochester's version of the hotdog! And don't miss the nearby Finger Lakes region with its wine trails and gorges.

A rich 300-year history, a thriving arts community and seemingly endless wilderness make this New York capital city on the Hudson River a great weekend getaway. Outdoor enthusiasts come here to ski, hike, canoe and fish; trout and small-mouth bass fishing is among the best in the U.S. Mountains surround the city, and the tapestry of golds and reds on an autumn day is breathtaking. The city is dominated by an elaborate 10-building complex that includes the State Capitol; the New York State Museum, with life-like dioramas such as American Indian life and an Adirondack logging operation; and the oval-shaped Empire State Performing Arts Center, nicknamed "The Egg." History buffs will enjoy the colonial homes, historic churches and museums, and can tour 18th-century mansions, like the Schuyler, a superb example of pre-Revolutionary War architecture. Whether nature or history is your passion, you'll find an abundance of both in this upstate New York gem.

In Santander, enjoy the beautiful beaches of Playa de la Magdalena and El Sardinero, a historic city center, and an epic planetarium, all while breathing in glorious coastal air. Of course, there are plenty of gorgeous Gothic cathedrals that will impress and inspire.