If you’re into eating locally and supporting sustainable agriculture, go to Asheville—and eat, eat, eat. This town of less than 100,000 people has 17 farmers’ markets, and the local restaurant scene is all about taking advantage of the seasonal produce sold there. And don’t miss the area’s microbreweries.

A mixture of urban chic and outdoor adventures, Spokane has something for everyone. Taste food by James-Beard-nominated chefs at Sante or The Wandering Table. Listen to live music at The Bartlett or the symphony at the iconic Martin Woldson Theater at The Fox. Glide over the breathtaking Spokane Falls, situated right downtown, in the SkyRide, rated as one of the world’s best gondolas. Kids can feed the Garbage-Eating Goat or slide down the giant Radio Flyer Red Wagon in Riverfront Park.

It seems like every time of year is "in season" in Lenox, a small Berkshire town that has been a popular retreat since the 19th century. In summer, picnic on the lawn at Tanglewood, the Boston Symphony Orchestra's summer home. In fall, when foliage peaks, take to the hiking and biking paths of the Pleasant Valley Sanctuary to immerse yourself in the vibrant colors of the mountains. Winter visitors enjoy skiing at a number of resorts and cross-country trails, and in spring, hikers and golfers practice their pastimes in splendid settings. Rejuvenating treatments and pampering, at the well-known Cranwell Spa, are favored all year long.

The glowing Mosquito Bay is a vision of bizarre beauty. Thanks to a bioluminescent microorganism, the water is a cool electric blue, looking somewhat like a fantastical sci-fi lagoon. Kayak or hop into a clear-bottomed pontoon boat to glide along the neon waters. Swimmers and snorkelers will adore the pristine, undeveloped beaches. Keep an eye out for the playful feral horses that gallop along the dunes, or visit the stately ceiba tree that’s been keeping watch over the highland for three centuries.

Lush and luxuriant, the exotic tropical island nation of St. Kitts and Nevis is a romantic paradise. St. Kitts' wonderful beaches remain relatively crowd-free, and nature lovers delight in seeing lava formations, tropical forest and lagoons and underwater marvels while snorkeling or diving. Among more than 200 historical sites, former plantation homes now offer elegant accommodation. Eco-rambles, bio-tours and climbing are Nevis attractions. Rent cars or mopeds on-island and catch ferries between the two.

The epic Moai stone statues that stand guard over Easter Island are among the main attractions of this remote and lonely part of the world. Hanga Roa is Easter Island’s commercial hub and its only village. The airport is here, as are several restaurants, guest houses and hotels. Use it as a base for island adventures, which may include trekking, exploring white sand beaches, snorkeling, diving, visiting archaeological sites or even your own private spiritual journey.