The largest city in Switzerland is a major contemporary art and shopping destination. Important artworks are displayed in the Kunsthaus and the Rietberg Museum, while those who consider shopping an art can hone their skills along Bahnhofstrasse and Niederdorf. Chagall's stained glass windows in the Fraumunster amaze and Zurich's 500 clubs and bars, including several in swimming pools, pulse with life 'til the early hours. This city on Lake Zurich has excellent public transit and a free bike rental system.

Even if you’ve never been to this Cyclades island in the Aegean Sea, you’d still recognize it immediately – candy-colored houses carved into cliffs, sapphire waters, gleaming white buildings topped with half-spheres the color of a stormy sky. Here you’ll find peace as you roam the black sand beaches or the streets of a provincial village like Imerovigli. Beautiful Oia is world famous for its sunsets, which seem tinted with every shade of an artist’s palette.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

Located in the very Northwest corner of Pennsylvania, Erie is the State's only Great Lakes port city. The Lake is the main attraction in Erie, with the sparkling water giving Erie its nickname, "Gem City." The nearby peninsula of Presque Isle State Park provides residents and visitors ample opportunities for outdoor activities such as sailing, swimming, hiking, and biking. The city is also part of the Snowbelt, famous for the winter wonderland created by the lake effect.

The festive city of San Juan is the perfect place to experience true Puerto Rican culture. Get to know its roots by exploring the vibrant neighborhood of El Viejo San Juan (Old San Juan), which consists mostly of Spanish colonial buildings. Flesh out your self-guided history lesson with a visit to El Castillo San Felipe del Morro, a 16th century citadel that’s a UNESCO World Heritage Site. Then reward yourself with a cooling dip at Luquillo or Carolina Beach, then a tasty tour of the Bacardi rum plant.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.

This tiny twin island republic offers an enticing mix of cultural activities and eco adventure. Located just off the tip of Venezuela, lively Trinidad, the larger of the two, boasts energetic nightlife in modern capital Port-of-Spain. Driving on the North Coast Road reveals lush forest and breathtaking views. Tobago, two hours away by fast ferry, is comparatively serene. Azure seas contrast with pale pink sands and golden sunsets. Protected rainforest and stunning coral reefs complete this paradise.

One of the top diving destinations in the world for its bright storybook coral reefs, the island of Cozumel is also home to a variety of natural beaches. Choose a beach with soft white sand for relaxing, or snorkel off a rockier vista. A destination for both adventure and romance, Cozumel has a year-round Caribbean climate, untrammeled jungle and abundant nightlife.