Just its location—in the Sacred Valley of the Incas—makes Urubamba sound like a mystical, magical place. The snow covered Ch'iqun mountain stands proudly in the background of this Peruvian town that serves as a base for people who want to visit the famous ancient Incan ruins of Machu Picchu. Zip lines and horseback rides let you experience this valley in the Andes in wildly different ways.

Ollantaytambo has some of the oldest continuously-occupied buildings in South America. Once a stronghold of Inca resistance to Spanish colonization, it's remarkably well-preserved. Many travelers visit Ollantaytambo because it's the beginning of the Inca Trail to Machu Picchu, but don't rush through—the ruins are fascinating.

It's no wonder Machu Picchu is Peru's most-visited site. Dating to the mid-1400s, it's a marvel of mortar-free limestone architecture perched on a high plateau deep in the Amazonian jungle. Get there via train from Cusco or, if you're not faint-hearted, make the trip on foot via a multi-day hiking trail—you'll travel through deep Andean gullies and enjoy stunning views.

Peru’s Aguas Calientes offers weary travelers the chance to soak in thermal baths and browse for artisan souvenirs before (or after) using the town as a gateway to Machu Picchu. Its remote location deep in the Urubamba Valley is accessible to tourists only by train.

Vibrant Salta is a mashup of old world architecture and modern fun—a truly sophisticated bohemia! Marvel at the intricate façade of the old town hall—a Salta focal point—as you stroll from museums to markets. Savor the vintages at local wineries or take a train to a tiny village that's perched "at the top of the clouds." Thrill seekers will love the adventure sports and archaeological explorations that await at nearby Cabra Corral Dam.

Set in rugged, mountainous territory in the east, Cuba's fourth largest city is known as the City of Parks. Columbus called the area "the most beautiful land eyes have ever seen" and much of the surrounding area hasn't changed. Officially called San Isidro de Holguin, the city's elegant plazas, scatter of colonial buildings and few museums make for a pleasant daytrip. More wonders lie offshore. Swim with dolphins in Bahia de Naranjo Nature Park. Dive to sites off Playa Esmeralda and Guardalavaca.

Greenville, South Carolina, is anchored by what Forbes Magazine calls one of America's Best Downtowns. Featuring a one-of-a-kind "floating" suspension bridge and set against the scenic Blue Ridge Mountains, Greenville boasts a thriving arts scene, hundreds of restaurants, shops and boutiques, popular annual festivals, numerous historic sites and museums housing significant art collections. Excellent interstate service and a user-friendly international airport make access easy.

Costa Adeje, on the southern side of Tenerife in the Canary Islands, is home to many newly-developed hotels that draw chic European guests. You’ll find great shopping (in boutiques and markets) and upscale restaurants, as well as plenty of sunny weather.