Llamas, sheep and alpacas roam the plains of Puno, a port city in southeastern Peru. Their fleeces are used to make the area’s signature textiles, which make excellent souvenirs. You’ll do a lot of walking here, as many of the streets are too steep for cars. But the climbs are worth it for the excellent views of Lake Titicaca. Take a boat to the Floating Islands or get up close and personal with the four-legged locals at a llama farm.

Laid-back colonial gem San Jose Del Cabo is picture-postcard perfect. This gorgeous getaway, with its palm-lined lagoons on the hem of the ocean, is full of the magic of Old Baja, where secret courtyards and unhurried days promise intrigue and romance. Fine hotels abound, including the elegant, world-renowned One&Only Palmilla.

Venture into the unspoiled beauty of 7,000-foot Rocky Mountain vistas, marvel at the contrast of ancient native culture mixed with modern arts, feast on legendary cuisine and relax in rustic sophistication. A visit to Santa Fe, Travel & Leisure's #1 Cultural Getaway, feels a lot like a visit to Europe. The Spanish Colonial charm of this historic destination has been enchanting travelers for over 400 years. And Santa Fe shows no signs of slowing down.

The acclaimed Rancho La Puerta is Mexico's top destination spa. Set within spectacular grounds, just an hour from San Diego, therapeutic treatments make full use of all kinds of medicine and produce from the Rancho's organic garden. This idyllic sanctuary is a luxurious full service spa resort.

Beyond its epic theme parks and perfect weather, Orange County is celebrated for outdoor dining, entertainment and beach-bound adventure. Treat yourself at South Coast Plaza for the finest in luxury shopping and superlative restaurants. Spend an afternoon aboard a whale watching cruise in Newport Harbor, or cast a reel from the Huntington Beach Pier. Stop to smell the flowers at the Sherman Library and Gardens, or explore Laguna’s vast variety of boutique shops along the Pacific Coast Highway.