Vietnam's bustling largest city sets the cultural and economic pace for the country. The former Saigon boasts charming French colonial architecture and wide boulevards, usually thronged and choked with traffic. Taxis are an option for seeing the sprawling city. The War Remnants Museum shows the Vietnam War through Vietnamese eyes. Don't miss the impressive Jade Emperor Pagoda. Go to the frenetic Ben Thanh Market for food, flowers or frogs. Tour through the Mekong Delta, past rice paddies and houseboats.

Metropolitan Manila encompasses six cities and 12 towns. Located on Manila Bay in the South China Sea, and bisected by the Pasig River, the capital of the Philippines is historic and modern, rich and poor. A popular sight is the walled area called Intramuros. The capital during Spanish colonization, Intramuros has retained old dungeons and gunpowder rooms but added art galleries and theaters. The city is filled with museums, shops, parks and churches, plus enough nightlife to last until dawn.

Diverse marine life and hundreds of Red Sea coral reef sites make Sharm El Sheikh a magnet for divers and eco-tourists. The tourist economy of this Sinai Peninsula city has grown quite rapidly over the last few decades, resulting in an upcrop of first-class resorts and posh nightlife. The waters of Ras Mohamed National Park are abundant with schools of fish and, oddly, toilets – thanks to the bathroom fixtures being transported by a cargo ship that sank during a 1981 storm.

Perched on a hilltop in northern Malta, laid-back Mellieħa has a more local feel than many of the island's more developed southern resort towns. You'll find Malta's longest beach here, the white-sand Mellieħa (or Għadira) Bay.

The largest and many say most beautiful island in the Bay of Naples, Ischia is renowned for its curative spas. Ferries and hydrofoils connect Naples to Ischia Porto, the main town. Nearby at Ischia Ponte (connected to the main island by a foot bridge) are the magnificent Castello Aragonese and Guevara Tower. Forio on the island’s west coast, Lacco Ameno in the northwest and Sant’Angelo in the south are the liveliest resort towns. Casamicciola Terme in the north is one of Europe’s oldest spas.

Sitting where the Phoenician colony of Hadrumetum once stood nearly 3,000 years ago, the modern-day Sousse is a resort destination, especially popular with Europeans. Sometimes called "the Pearl of the Sahel" (referring to the central section of Tunisia's eastern shoreline), Sousse is prized for its excellent beaches. Arab-Islamic since the 7th century AD, the city has many fascinating attractions, like the 9th-century Great Mosque, and its medina is a UNESCO World Heritage Site.

When most people think of Zermatt, they think of one thing: The Matterhorn. This ultimate Swiss icon looms over Zermatt, first drawing visitors here in the 1860s. The village of Zermatt itself is lovely and car-free, with old-fashioned brown chalets and winding alleys. (Don’t worry, you don’t have to walk everywhere—there are electric vehicles and horse-drawn cabs.) Skiing in the region often lasts through early summer, but when the weather’s warmer, it’s a great time to hike.