Vietnam's bustling largest city sets the cultural and economic pace for the country. The former Saigon boasts charming French colonial architecture and wide boulevards, usually thronged and choked with traffic. Taxis are an option for seeing the sprawling city. The War Remnants Museum shows the Vietnam War through Vietnamese eyes. Don't miss the impressive Jade Emperor Pagoda. Go to the frenetic Ben Thanh Market for food, flowers or frogs. Tour through the Mekong Delta, past rice paddies and houseboats.

Palawan is a slice of heaven, a sliver of an island that teems with exotic wildlife, quaint fishing villages, and UNESCO World Heritage Sites. Wave hello to endangered animals at the Calauit Game Preserve and Wildlife Sanctuary or explore the Japanese shipwrecks of Coron Island, regarded as one of the best dive sites in the world. A guided boat tour of the Puerto Princesa Underground River will take your breath away.

Tagaytay secures its place on most Philippines itineraries with its location above Taal Volcano's active crater. Views of the crater lake and a refreshingly cool climate make the town an enticing destination—not to mention the famously unfinished People's Park in the Sky.

The biggest island in the Philippines, Luzon is also one of the most diverse—it’s where mountain peaks and volcanoes meet miles of coastline, and indigenous culture melds with Spanish colonial history. You can relax at the beach in Pagudpud, hike with locals up the Batad Rice Terraces, ride in a horse-drawn carriage in Vigan, and snack on street food and dance the night away in Manila. You’ll need a few days and a bus pass, but you’ll be glad you stayed.

Resorts and reefs are the draw on Israel’s skinny Red Sea coastline, and Eilat tempts visitors with sun that lasts all year round. Sandy beaches, warm waters, and nightlife complete the package, along with desert scenery that’s just beyond the crowded coast.

Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)