Located on the east coast of Belize at the mouth of the Belize River, Belize City sits on a peninsula jutting into the Caribbean Sea. As the nation's main port, the city is a hub for cruise ships and is often a jumping-off spot for excursions to other parts of Belize, including the Cayo District's caves and Maya archaeological sites along the Macal and Belize rivers. Belize City boasts the only manual swing bridge in the world and the oldest Anglican cathedral in Central America.

Love culture, not crowds? Leave the bustle of Belize City for quieter Dangriga, at the end of the Hummingbird Highway. The town is a suitable base for exploring the Stann Creek district: visit the Maya Center and the world's first jaguar preserve, explore the beach and try snorkeling at the reef a few miles out.

Smaller and more intimate than popular resort areas such as San Ignacio and Belize City, the modest capital of Belmopan is nonetheless a vibrant city surrounded by stunning scenery and wildlife. Next to the bustling Market Square, Independence Plaza is home to the prime minister's offices, various pedestrian pathways and the National Assembly Building, designed to resemble a Mayan temple. Outside the city lay the spectacular Guancaste Park as well as the astonishing Hummingbird Highway.

Located near the Mexico-Belize border, a true paradise awaits travelers in Bacalar. The town sits on the Lagoon of Seven Colors, a lake nicknamed for its beautifully colored water, which makes it the perfect place for stunning sunsets, fresh seafood, and cenote swimming.

It’s true: parts of Belize are getting touristy. But San Ignacio remains rustic, making it a great base for budget-friendly tropical adventure travel. Canoe on the Macal River, or walk to Mayan ruins at Cahal Pec (just be warned: it's uphill).

Once a sleepy fishing village, Placencia has emerged as an increasingly popular eco-destination on the Caribbean. For those who enjoy outdoor adventure, the Stann Creek region offers a host of activities: hiking through mountainous rain forests, kayaking, deep sea fishing, diving and exploring Mayan ruins. The peninsula boasts 16 miles of tranquil beaches, with a lagoon to the west and the Caribbean to the east and lots of peace and quiet in the middle. Tour guides and dive centers offer a variety of excursions, with boat rides to the outer cayes an ongoing favorite. Also popular are guided land tours to Mayan Ruins or trekking the jungle trails of Cockscomb Basin Wildlife Sanctuary, where the first Jaguar Reserve in the world was established.

Though famously home to Duke University, Durham, North Carolina, is more than just a college town. Nasher Museum of Art and the Museum of Life and Science show off Durham’s cultural side, while pretty parks and a dynamic dining scene add to its appeal.

You’ll wonder why you don’t live in Portland after you’ve visited this laid-back and friendly city. With a reputation for manicured parks, eclectic nightlife, fine micro-breweries and distilleries, and nature that cuts right into the city, Portland’s a Pacific Northwest must-visit. Don’t miss the famous Japanese Garden, one of the largest and most beautiful of its kind outside of Japan.

Giant anteaters, howler monkeys, ocelots, endangered jaguars and clouds of butterflies are among the attractions at this World Heritage-designated park that marks the border between Brazil and Argentina. By foot or by raft, explorers can view one of the world's most stunning waterfalls, Iguazu Falls. Among the park's 270 waterfalls, spectacular Devil's Throat combines 14 falls and generates a "perpetual rainbow" in good weather.

Lanzarote’s largest resort area has much to offer visitors—in addition to the fine beaches, you’ll find casinos, great shopping, and tons of restaurant options. Puerto Del Carmen’s nightclubs and large hotels are a big draw for a youthful European crowd.