Just north of Cancun, this seaside resort community is a far cry from the spring-break crowd. Bordered on one side by the Mexican Caribbean and the other by a wetlands wildlife preserve, the vibe in Playa Mujeres is one of laid-back luxury in a natural, untouched landscape. Unlike many other such tranquil places, Playa Mujeres is not a pain to get to. It's an easy ride from Cancun airport.

Puerto Rico offers the perfect balance of rum-soaked nightlife and tranquil retreat. The Spanish colonial buildings of San Juan set a perfect backdrop for a day of shopping and sightseeing. Hike the massive El Yunque rainforest to see waterfalls, stone towers, and colorful Puerto Rican wildlife. As far as beaches go, it doesn’t get better than the private sands of Isla de Vieques – particularly Mosquito Bay, where by moonlight the water glows blue-green thanks to magical microorganisms.

The festive city of San Juan is the perfect place to experience true Puerto Rican culture. Get to know its roots by exploring the vibrant neighborhood of El Viejo San Juan (Old San Juan), which consists mostly of Spanish colonial buildings. Flesh out your self-guided history lesson with a visit to El Castillo San Felipe del Morro, a 16th century citadel that’s a UNESCO World Heritage Site. Then reward yourself with a cooling dip at Luquillo or Carolina Beach, then a tasty tour of the Bacardi rum plant.

Enjoy an old-fashioned beach vacation, complete with a boardwalk, at one of Delaware's most popular resort towns. Long a traditional summer getaway for families, Rehoboth Beach is now also a favorite of gay and lesbian travelers. Serious golfers will want to test their skills at the Kings Creek Country Club, while Old Landing Golf Course offers great views of the local scenery. Along with enjoying the famous beach and strolling the boardwalk, there's also a nearby amusement park called Funland to check out.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

Hollywood beckons to tourists who long for a brush with Tinseltown glamor. Tour movie studios, slip your hands into the famous prints at the TCL Chinese Theatre, or indulge in a celeb sighting at one of LA’s white-hot nightspots. Spot your favorite star while shopping at The Grove, or forget all about the famous eye candy as you take in the iconic artwork at The Getty Center. For a different type of star-gazing, peek through the telescopes at the Griffith Observatory.

Nevada's "other" gambling and resort town, Reno is located in the western part of the state near the California border. What the city lacks in glitz or reputation it more than makes up for in attractions and amenities. There are first-rate hotels, golf courses and casinos to rival its southern counterpart and, also like Las Vegas, Reno has become a popular destination for families. Galena Creek Park offers nature trails that even young children can navigate, plus organized educational events for families.

With the distinctive Haystack Rock and Needles marking its shoreline, Cannon Beach is one of Oregon's quaintest and most picturesque destinations. Nine miles of beach make a perfect setting for strolling along the seaside, watching diverse wildlife in its natural habitat and building a sand castle in the annual sand castle building contest. With strict regulations in place limiting the infiltration of large chain stores or restaurants, Cannon Beach retains its small town charm.

Vancouver was founded as “Gastown” by an Englishman with a penchant for beer and storytelling. Today Gastown is a historic section of the Canadian metropolis, and the lively pubs still reflect the area’s former status as a sort of community drinking center. The city’s forests, grand parks, and impressive suspension bridge beckon travelers to explore them, as do the city’s shops and museums. Relive the glory of the 2010 Winter Games with visits to Olympic venues and the marvelous Olympic Cauldron.