San Pedro is "La Isla Bonita" that Madonna made famous. Now it's a tourist mecca, but still boasts great beaches and plenty of dive shops so you can enjoy the sun, sand, and sea. Plan a side trip to Caye Caulker while you're here; it is less developed and more laid back, and has its own splendid swimming areas.

Ambergris Caye hovers in a vacation sweet spot: just enough amenities to make it exciting, but not so overdeveloped that you’re tripping over flip-flopped tourists. A mangrove swamp is the eye of this white beach island, the largest in Belize, and golf carts are the main form of transportation along the sandy roads. Reef divers drool over the Belize Barrier Reef and the Blue Hole, a 400-feet deep circle of limestone that teems with angelfish, elkhorn coral, cleaner shrimp and stalactites.

Once a sleepy fishing village, Placencia has emerged as an increasingly popular eco-destination on the Caribbean. For those who enjoy outdoor adventure, the Stann Creek region offers a host of activities: hiking through mountainous rain forests, kayaking, deep sea fishing, diving and exploring Mayan ruins. The peninsula boasts 16 miles of tranquil beaches, with a lagoon to the west and the Caribbean to the east and lots of peace and quiet in the middle. Tour guides and dive centers offer a variety of excursions, with boat rides to the outer cayes an ongoing favorite. Also popular are guided land tours to Mayan Ruins or trekking the jungle trails of Cockscomb Basin Wildlife Sanctuary, where the first Jaguar Reserve in the world was established.

The Cayman Islands are made up of three islands: Grand Cayman, Cayman Brac and Little Cayman. The largest, Grand Cayman has a cosmopolitan vibe, gourmet restaurants, world-class diving and the famous Seven Mile Beach. Cayman Brac is a nature lover's heaven of stunning diving and breathtaking walks along the rocky bluff. The smallest island, Little Cayman is home to just 150 people. Visitors enjoy the relaxed atmosphere and diving, especially Bloody Bay Wall, considered one of the world's best wall dives.

The festive city of San Juan is the perfect place to experience true Puerto Rican culture. Get to know its roots by exploring the vibrant neighborhood of El Viejo San Juan (Old San Juan), which consists mostly of Spanish colonial buildings. Flesh out your self-guided history lesson with a visit to El Castillo San Felipe del Morro, a 16th century citadel that’s a UNESCO World Heritage Site. Then reward yourself with a cooling dip at Luquillo or Carolina Beach, then a tasty tour of the Bacardi rum plant.

Giant anteaters, howler monkeys, ocelots, endangered jaguars and clouds of butterflies are among the attractions at this World Heritage-designated park that marks the border between Brazil and Argentina. By foot or by raft, explorers can view one of the world's most stunning waterfalls, Iguazu Falls. Among the park's 270 waterfalls, spectacular Devil's Throat combines 14 falls and generates a "perpetual rainbow" in good weather.

The historic quarter of Colonia del Sacramento, founded in 1680, evokes old Lisbon with its Portuguese-influenced architecture and winding streets. The area, located in southwestern Uruguay on the Rio de la Plata, was named a UNESCO World Heritage site in 1995. It's an easy day trip by ferry from Buenos Aires, making the beaches a popular Argentinean escape. Major sights include Iglesia Matriz, the country's oldest church, the Municipal Museum and a 17th-century port jutting into the river.