Tagaytay secures its place on most Philippines itineraries with its location above Taal Volcano's active crater. Views of the crater lake and a refreshingly cool climate make the town an enticing destination—not to mention the famously unfinished People's Park in the Sky.

Metropolitan Manila encompasses six cities and 12 towns. Located on Manila Bay in the South China Sea, and bisected by the Pasig River, the capital of the Philippines is historic and modern, rich and poor. A popular sight is the walled area called Intramuros. The capital during Spanish colonization, Intramuros has retained old dungeons and gunpowder rooms but added art galleries and theaters. The city is filled with museums, shops, parks and churches, plus enough nightlife to last until dawn.

Surpassed only by Manila in size, the Philippines’ second city combines colonial architecture and mountainous surrounds with a burgeoning cultural and culinary scene. As the gateway to both Bohol and Cebu Island, Cebu City impresses with chic rooftop bars and intriguing museums.

Puerto Princesa’s claim to fame goes way beyond its swanky beach resorts and dolphin-watching cruises. The UNESCO-listed Underground River wows visitors with its low-hanging stalagmites and stalactites, and a cave that—due to its sheer size and rock formations resembling religious figures—is likened to a cathedral.

A visit to Pattaya is a wonderful way to explore the beaches along the Gulf of Thailand. Relaxed and family-friendly Jomtien Beach is a hot spot for watersports and seaside massages. The giant Buddha of Wat Khao Phra Bat keeps watch over the city, and the wooden Wang Boran Sanctuary of Truth pays homage to Buddhist and Hindu art and architecture. At night, tons of bars and strip clubs attract an adults-only crowd.

Tradition collides with pop culture in Tokyo, where you can reverently wander ancient temples before rocking out at a karaoke bar. Wake up before the sun to catch the lively fish auction at the Toyosu Market, then refresh with a walk beneath the cherry blossom trees that line the Sumida River. Spend some time in the beautiful East Gardens of the Imperial Palace, then brush up on your Japanese history at the Edo-Tokyo Museum. Don’t forget to eat as much sushi, udon noodles, and wagashi (Japanese sweets) as your belly can handle.

Colombo is the gateway to Sri Lanka for most travelers—but don’t be tempted to simply pass through this diverse and interesting city. Take a train ride along the coast to Mount Lavinia, a popular beach, or explore the Talangama Wetland, which several TripAdvisor travelers say is the perfect place to take a break from the bustling streets of the city.

The Omani city of Muscat is predominantly populated by Islamic Arabs, though it also has a sizable, non-resident Indian population, further rounded out by American, British and Dutch citizens. Muscat is a tolerant and progressive city, where English speakers are relatively common. Arrange fares beforehand if seeing the city by taxi. To explore further, consider renting a car. Don't miss the imposing Sultan Qaboos Grand Mosque, atmospheric Old Muttrah Souk, Al Alam Royal Palace or Al Jalali Fort.

Dubai is a destination that mixes modern culture with history, adventure with world-class shopping and entertainment. Catch a show at the Dubai Opera, see downtown from atop the Burj Khalifa and spend an afternoon along Dubai Creek exploring the gold, textile and spice souks. If you’re looking for thrills, you can float above the desert dunes in a hot air balloon, climb aboard a high-speed ride at IMG Worlds of Adventure or skydive over the Palm Jumeirah.