Nestled in the fertile Susquehanna Valley, Harrisburg has played a pivotal role in the shaping of American history, both as a major link in rail and water transportation and as the setting of major Civil War battles. Having bounced back from economic distress in the 1980s, the city is now a vibrant hub of family activities, from cruises along the Susquehanna to arcades and athletics on City Island. The annual Pennsylvania Farm Show is the largest indoor agriculture exposition in the U.S.

Pittsburgh has been remade and reimagined. Think 24 miles of riverfront trails, beautiful parks and historic attractions. Home to 90 neighborhoods, the ‘Burgh feels authentic and unpretentious. No visit is complete without a trip to the Strip District or PNC Park, a ride up the Duquesne Incline or a stop at The Andy Warhol Museum. Architecture buffs love Pittsburgh for the amazing downtown buildings. Hollywood producers, do, too—the city has even been called the “Hollywood of the East."

Palm Beach has long lured America's big name social elite, from the Kennedys to the Pulitzers to the Trumps. If you don't have the Jaguar, catch a Palm Tram around the city. Opulent extravagance is the order of the day. But if you can take your eyes off the glittering procession of socialites and the prices at Donald Trump's Mar-a-Lago Spa and in Worth Avenue stores, there are plenty of other sights to be seen. Don't miss Henry Morrison Flagler Museum or the hopping nightlife on Clematis Street.

Stretching 126 miles south toward Cuba, the stunning Keys are a perfect escape. Highlights along the way include Key Largo, Islamorada, Marathon, Big Pine Key and the irrepressible Key West. Get up close with an amazing array of fish while snorkeling, diving or fishing in the warm turquoise waters. Creeks, coral and costumed spectacles are other lures along the way. Highway 1 is a spectacular ribbon tying together the islands and atolls of this paradise between the Gulf of Mexico and the Atlantic.

The Texas Rangers and Dallas Cowboys both make their home in Arlington. Midway between Dallas and Fort Worth, the city has long been home to Rangers baseball and now also hosts the Cowboys. Their state-of-the-art structure is the world’s largest domed arena. Visitors looking for other adventures can enjoy the original Six Flags Over Texas and Hurricane Harbor water park, along with shopping, golf and nightlife. Arlington also has a vibrant culture of live music, symphony, museums and theater.

Whether you’re a high roller or a low-key lounger, Las Vegas has something to suit your vacation taste. Sample fare from top chefs and cornucopian buffets, try your luck at one of the world’s premier casinos, or take in a spectacular show. Just wandering the Strip is enough to get your heart pumping. Once you’ve had enough of the razzle-dazzle, wave hello to the toothy sea life at the Mandalay Bay Shark Reef, hike Red Rock Canyon, or visit the Neon Museum, where old signs take on new life.

A city of natural beauty, charm, history and western hospitality, this state capital derived its name from Kit Carson, the legendary trapper, scout and explorer. A trip to the city is a living history lesson. One need only jump on the Kit Carson Trail downtown, which passes old mansions, courthouses, a depot and a brewery, to experience a taste of life in the Old West. Also downtown, the State Capitol, built in 1870, offers a look at the birth of Nevada as a state and Carson City as its capital. Other historic landmarks, cultural heritage centers and museums dot the landscape around town, but don't forget your clubs. The city is well-known for the Divine Nine, a group of top-rated area courses designed by pros such as Arnold Palmer, Johnny Miller and John Harbottle and set amid the magnificent Sierra Mountains. After a little golf, gambling or sightseeing, spend some down time at the Carson City Hot Springs. You will emerge feeling relaxed, rejuvenated and ready for more exciting endeavors.

Hollywood beckons to tourists who long for a brush with Tinseltown glamor. Tour movie studios, slip your hands into the famous prints at the TCL Chinese Theatre, or indulge in a celeb sighting at one of LA’s white-hot nightspots. Spot your favorite star while shopping at The Grove, or forget all about the famous eye candy as you take in the iconic artwork at The Getty Center. For a different type of star-gazing, peek through the telescopes at the Griffith Observatory.

Every neighborhood in San Francisco has its own personality, from the hippie chic of the Upper Haight to the hipster grit of the Mission. The Marina district boasts trendy bistros and postcard-perfect views of the Golden Gate Bridge, while Noe Valley offers quaint and quiet boutiques. Wave hello to the sea lions at Pier 39, and sample local cheese and charcuterie at the Ferry Building. Sit in on a yoga session in Dolores Park or marvel at the Dutch Windmill across from Ocean Beach.