Lucerne is an ancient town with strikingly modern sensibilities. One of Europe’s oldest covered bridges serves as its centerpiece, and fresco-adorned historic houses line the streets, but it’s also home to the cutting-edge KKL, a concert hall and art gallery. Take the cableways up the Pilatus, Stanserhorn or Rigi mountains for breathtaking views, or see Lake Lucerne on a steamship cruise.

Popular in the late 18th and early 19th century with luminaries such as Strauss, Wagner, Kafke, Freud, Twain and Edward VII, this sprightly spa town is a charming spot. Delicately painted spa houses and hotels tiptoe up the lush, forested mountainsides. One hundred mineral springs with high carbon dioxide and iron content confetti the town and nearby hillsides, many with neat colonnades and stately pavilions. The most famed is the cupola-capped and colonnade-adorned Krizovy pramen.

Darjeeling, nestled among rolling mountains, is a perfect destination for outdoor enthusiasts. Popular places to visit include Tiger Hill, Batasia Loop and the War Memorial, and the Himalayan Zoological Park and Snow Leopard Breeding Center. What should you bring home? Tea, tea, and more tea—and beautiful local handicrafts.

Essen began in the mid-9th century as home to a women's abbey, then during the Renaissance became an important coal mining town and later a major steel production center. The famed metal-working Krupp family opened their first foundry here in 1810. One of Essen's most interesting places is the Zollverein Coal Mine Industrial Complex, once the largest colliery in the world. Now a UNESCO World Heritage Site, it attracts 800,000 visitors a year, often hosting art exhibitions and performances.

Belgium's fourth-largest - and most beautiful - city is home to a quarter of a million people and a flourishing flower export trade. An important port, Ghent's city center is a pedestrian area that is like a museum to early Flemish architecture and a testament to the city's medieval might. Impressive Gothic sites, such as dramatic St. Bavo's Cathedral and the Castle of the Counts, inspire awe. The works of Flemish masters are housed in the distinguished Museum voor Schone Kunst.

The charming Vietnamese capital has aged well, preserving the Old Quarter, monuments and colonial architecture, while making room for modern developments alongside. Hanoi may have shrugged off several former names, including Thang Long, or "ascending dragon," but it hasn't forgotten its past, as sites such as Ho Chi Minh's Mausoleum and Hoa Lo Prison attest. Lakes, parks, shady boulevards and more than 600 temples and pagodas add to the appeal of this city, which is easily explored by taxi.